PSORIATIC ONYCHODYSTROPHY: CLINICAL MANIFESTATIONS (PART 1)

Psoriatic onychodystrophy: clinical manifestations (part 1)

Psoriatic onychodystrophy is quite common in patients with psoriasis.Changes in psoriatic nails have a wide range of clinical manifestations, including symptoms of damage Earthrise of the nail bed and/or nail matrix.The article presents information about clinical and pathological manifestations of psoriatic onychodystrophy, the mechanisms of format

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KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement

Abstract Background Orthodontic tooth movement (OTM) is a dynamic equilibrium of bone remodeling, involving the osteogenesis of new bone and the osteoclastogenesis of old bone, which is mediated by mechanical force.Periodontal ligament stem cells (PDLCSs) in the periodontal ligament (PDL) space can transmit mechanical signals and regulate osteoclas

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BLA DBS improves anxiety and fear by correcting weakened synaptic transmission from BLA to adBNST and CeL in a mouse model of foot shock

Summary: Deep brain stimulation (DBS) in the basal lateral amygdala (BLA) has been established to correct symptoms of refractory post-traumatic stress disorder (PTSD).However, how BLA DBS operates in correcting PTSD symptoms and how the BLA elicits pathological fear and anxiety in PTSD remain unclear.Here, we discover that excitatory synaptic trans

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Genetics of primary congenital hypothyroidism: three decades of discoveries and persisting etiological challenges

Primary congenital hypothyroidism (CH) is the most common neonatal Seat Post endocrine disorder, and may be etiologically subdivided into thyroid dysgenesis, referring to abnormal thyroid development, and dyshormonogenesis, where a defective thyroid hormone biosynthesis pathway results in inadequate hormone production despite a structurally intact

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